Firecrawl Alexandria
ClinVar
ClinVar, NCBI's public archive of human genetic variants and their clinical classifications (4.7 million records), through NCBI E-utilities. Search variants by gene, HGVS name, rsID, canonical SPDI, condition or free text, filtered by germline classification, review status or star rating, variant type and molecular consequence; read one variant by VCV accession, variation ID, ClinVar URL, rsID or HGVS with its aggregate germline classification, somatic clinical impact and oncogenicity, review status and stars, conditions with MedGen, OMIM, MONDO, Orphanet and HPO IDs, per-condition RCV aggregates, and each submitter's classification with criteria, allele origin, method and cited PMIDs. Every output carries ClinVar's citation and its clinical-use disclaimer.
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const result = await firecrawl.scrape({
alexandria: {
provider: "clinvar-ncbi-nlm-nih-gov",
capability: "variants/get",
options: {
variant: "VCV000017661",
},
},
});2Response example
This is a sample shape. Press Run to see live data from ClinVar.
{
"license": {
"attribution": "Data from ClinVar, National Center for Biotechnology Information, U.S. National Library of Medicine (https://www.ncbi.nlm.nih.gov/clinvar/). Cite ClinVar, e.g. Landrum MJ et al., Nucleic Acids Res. 2018;46(D1):D1062-D1067 (PMID: 29165669).",
"disclaimer": "ClinVar's information is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. NIH does not independently verify the submitted information.",
"name": "Public domain (NCBI)",
"rights": "NCBI places no restrictions on the use or distribution of its molecular data; some submitters may claim rights in the data they submitted.",
"terms_url": "https://www.ncbi.nlm.nih.gov/clinvar/docs/maintenance_use/",
"url": "https://www.ncbi.nlm.nih.gov/home/about/policies/"
},
"observed_at_ms": 1793396497661,
"rcv_total": 14,
"rcvs": [
{
"clinical_impact": null,
"conditions": [
{
"ids": [
"MedGen:C2676676"
],
"name": "Breast-ovarian cancer, familial, susceptibility to, 1"
}
],
"germline_classification": {
"classification": "Pathogenic",
"last_evaluated": "2015-08-10",
"review_status": "reviewed by expert panel",
"stars": 3,
"submission_count": 27
},
"oncogenicity": null,
"rcv_accession": "RCV000019229",
"version": 63
},
{
"clinical_impact": null,
"conditions": [
{
"ids": [
"MedGen:C0677776"
],
"name": "Hereditary breast ovarian cancer syndrome"
}
],
"germline_classification": {
"classification": "Pathogenic",
"last_evaluated": "2026-02-03",
"review_status": "criteria provided, multiple submitters, no conflicts",
"stars": 2,
"submission_count": 10
},
"oncogenicity": null,
"rcv_accession": "RCV000047597",
"version": 44
},
{
"clinical_impact": null,
"conditions": [
{
"ids": [
"MedGen:C0027672"
],
"name": "Hereditary cancer-predisposing syndrome"
}
],
"germline_classification": {
"classification": "Pathogenic",
"last_evaluated": "2025-03-11",
"review_status": "criteria provided, multiple submitters, no conflicts",
"stars": 2,
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},
"oncogenicity": null,
"rcv_accession": "RCV000131902",
"version": 25
},
{
"clinical_impact": null,
"conditions": [
{
"ids": [
"MedGen:C3661900"
],
"name": "not provided"
}
],
"germline_classification": {
"classification": "Pathogenic",
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"review_status": "criteria provided, multiple submitters, no conflicts",
"stars": 2,
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},
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"rcv_accession": "RCV000159935",
"version": 88
},
{
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"conditions": [
{
"ids": [
"MedGen:C0346153"
],
"name": "Familial cancer of breast"
}
],
"germline_classification": {
"classification": "Pathogenic",
"last_evaluated": "2025-11-24",
"review_status": "criteria provided, multiple submitters, no conflicts",
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},
"oncogenicity": null,
"rcv_accession": "RCV000239114",
"version": 16
},
{
"clinical_impact": null,
"conditions": [
{
"ids": [
"MedGen:C1458155"
],
"name": "Breast neoplasm"
}
],
"germline_classification": {
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},
"oncogenicity": null,
"rcv_accession": "RCV000412714",
"version": 10
},
{
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"conditions": [
{
"ids": [
"MedGen:C0678222"
],
"name": "Breast carcinoma"
}
],
"germline_classification": {
"classification": "Pathogenic",
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},
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"rcv_accession": "RCV000415051",
"version": 11
},
{
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"conditions": [
{
"ids": [
"MedGen:C0919267"
],
"name": "Ovarian neoplasm"
}
],
"germline_classification": {
"classification": "Pathogenic",
"last_evaluated": "2018-12-01",
"review_status": "no assertion criteria provided",
"stars": 0,
"submission_count": 1
},
"oncogenicity": null,
"rcv_accession": "RCV000785199",
"version": 10
},
{
"clinical_impact": null,
"conditions": [
{
"ids": [
"MedGen:CN221562"
],
"name": "Breast and/or ovarian cancer"
}
],
"germline_classification": {
"classification": "Pathogenic",
"last_evaluated": "2019-06-11",
"review_status": "no assertion criteria provided",
"stars": 0,
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},
"oncogenicity": null,
"rcv_accession": "RCV001270967",
"version": 9
},
{
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"conditions": [
{
"ids": [
"MedGen:CN377757"
],
"name": "BRCA1-related cancer predisposition"
}
],
"germline_classification": {
"classification": "Pathogenic",
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},
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"rcv_accession": "RCV004802937",
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},
{
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{
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"MedGen:C2676676"
],
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},
{
"ids": [
"MedGen:C4554406"
],
"name": "Fanconi anemia, complementation group S"
},
{
"ids": [
"MedGen:C3280442"
],
"name": "Pancreatic cancer, susceptibility to, 4"
}
],
"germline_classification": {
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},
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},
{
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{
"ids": [],
"name": "Inherited ovarian cancer (without breast cancer)"
}
],
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},
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"rcv_accession": "RCV005646760",
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},
{
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{
"ids": [],
"name": "Inherited breast cancer and ovarian cancer"
}
],
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},
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},
{
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{
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"name": "BRCA1-related disorder"
}
],
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},
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"rcv_accession": "RCV006879033",
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}
],
"record": {
"date_created": "2015-09-29",
"date_last_updated": "2026-10-18",
"germline_explanation": "Pathogenic (1)",
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"record_status": "current",
"record_type": "classified",
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},
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},
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{
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{
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}
],
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],
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"submitter_org_id": "504863"
},
{
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{
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],
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"submitter": "Genetics Laboratory, Great Ormond Street Hospital NHS Foundation Trust, North Thames Genomic Laboratory Hub",
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},
{
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"submitter": "Cambridge Genomics Laboratory, East Genomic Laboratory Hub, NHS Genomic Medicine Service",
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{
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"unknown"
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{
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{
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{
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{
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{
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"stars": 1,
"submitted": "2025-06-13",
"submitter": "Laboratory of Genetics, Children's Clinical University Hospital Latvia",
"submitter_org_id": "509237"
},
{
"assertion_method": "ACMG Guidelines, 2015",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [],
"name": "BRCA1-related disorders"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-11-23",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV007843480",
"scv_version": 1,
"stars": 1,
"submitted": "2026-08-20",
"submitter": "Blueprint Genetics",
"submitter_org_id": "500188"
},
{
"assertion_method": "ACMG Guidelines, 2015",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"MedGen:C3661900"
],
"name": "not provided"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-11-22",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV002024711",
"scv_version": 4,
"stars": 1,
"submitted": "2025-08-19",
"submitter": "Revvity Omics, Revvity",
"submitter_org_id": "167595"
},
{
"assertion_method": "ClinGen BRCA1 V1.1.0",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"ORPHA:145",
"MedGen:C0677776"
],
"name": "Hereditary breast ovarian cancer syndrome"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-11-11",
"methods": [
"curation"
],
"origins": [
"germline"
],
"pmids": [],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV005848150",
"scv_version": 1,
"stars": 1,
"submitted": "2025-02-17",
"submitter": "German Consortium for Hereditary Breast and Ovarian Cancer, University Hospital Cologne",
"submitter_org_id": "506864"
},
{
"assertion_method": "ACMG Guidelines, 2015",
"classification": "Likely pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"OMIM:604370",
"MedGen:C2676676"
],
"name": "Breast-ovarian cancer, familial, susceptibility to, 1"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-09-28",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [
"7894493",
"19329713"
],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV006582311",
"scv_version": 1,
"stars": 1,
"submitted": "2025-10-10",
"submitter": "3billion",
"submitter_org_id": "507830"
},
{
"assertion_method": "ACMG Guidelines, 2015",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"MONDO:0700268",
"MedGen:CN377757"
],
"name": "BRCA1-related cancer predisposition"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-07-29",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [
"7894493",
"9525870",
"10447273",
"10788334",
"11102977",
"11278247",
"11320250",
"19594371",
"20180014",
"20345474",
"20507347",
"20569256",
"21324516",
"21503673",
"21965345",
"23695190",
"24728189",
"27433846",
"29492181"
],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV004823691",
"scv_version": 2,
"stars": 1,
"submitted": "2024-12-12",
"submitter": "All of Us Research Program, National Institutes of Health",
"submitter_org_id": "509529"
},
{
"assertion_method": "Assertion Criteria Germline",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"MONDO:0003582",
"MedGen:C0677776"
],
"name": "Hereditary breast ovarian cancer syndrome"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-06-27",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [
"26381082",
"20103620"
],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV007097383",
"scv_version": 1,
"stars": 1,
"submitted": "2025-09-01",
"submitter": "Department of Genomics, ADN Uruguay",
"submitter_org_id": "510148"
},
{
"assertion_method": "ARUP Molecular Germline Variant Investigation Process 2024",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"MedGen:C3661900"
],
"name": "not provided"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-06-09",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV000602706",
"scv_version": 5,
"stars": 1,
"submitted": "2025-01-28",
"submitter": "ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories",
"submitter_org_id": "25969"
},
{
"assertion_method": "ACMG Guidelines, 2015",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"MedGen:C2676676"
],
"name": "Breast-ovarian cancer, familial, susceptibility to, 1"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-05-27",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV005045920",
"scv_version": 1,
"stars": 1,
"submitted": "2024-05-27",
"submitter": "Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet",
"submitter_org_id": "1147"
},
{
"assertion_method": "ACMG Guidelines, 2015",
"classification": "Pathogenic",
"classification_type": "germline",
"clinical_impact_significance": null,
"clinical_impact_type": null,
"conditions": [
{
"ids": [
"MedGen:C3661900"
],
"name": "Not provided"
}
],
"contributes_to_aggregate": false,
"last_evaluated": "2024-04-30",
"methods": [
"clinical testing"
],
"origins": [
"germline"
],
"pmids": [
"10447273",
"10788334",
"11102977",
"14986830",
"15290653",
"16168118",
"18824701",
"19770520",
"21324516",
"21990134",
"24504028",
"24728189",
"27433846",
"30209399",
"31347298",
"32546644",
"7894493",
"8644702"
],
"record_status": "current",
"review_status": "criteria provided, single submitter",
"scv_accession": "SCV000778779",
"scv_version": 2,
"stars": 1,
"submitted": "2024-12-17",
"submitter": "Mayo Clinic Laboratories, Mayo Clinic",
"submitter_org_id": "500068"
}
],
"submissions_total": 77,
"variant": {
"canonical_spdi": "NC_000017.11:43106486:A:C",
"cdna_change": "c.181T>G",
"clinical_impact": null,
"gene_count": 1,
"genes": [
{
"gene_id": "672",
"hgnc_id": "HGNC:1100",
"symbol": "BRCA1"
}
],
"germline_classification": {
"classification": "Pathogenic",
"conditions": [
{
"ids": [
"ORPHA:145",
"MedGen:C2676676",
"MONDO:0011450",
"OMIM:604370"
],
"name": "Breast-ovarian cancer, familial, susceptibility to, 1"
}
],
"last_evaluated": "2015-08-10",
"review_status": "reviewed by expert panel",
"stars": 3
},
"location": {
"grch37": {
"chromosome": "17",
"cytoband": "17q21.31",
"start": 41258504,
"stop": 41258504
},
"grch38": {
"chromosome": "17",
"cytoband": "17q21.31",
"start": 43106487,
"stop": 43106487
}
},
"molecular_consequences": [
"missense variant",
"non-coding transcript variant"
],
"name": "NM_007294.4(BRCA1):c.181T>G (p.Cys61Gly)",
"oncogenicity": null,
"protein_changes": [
"C61G",
"C14G"
],
"record_status": "current",
"rsids": [
"rs28897672"
],
"source_url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/17661/",
"submission_count": 77,
"variant_type": "single nucleotide variant",
"variation_id": "17661",
"vcv_accession": "VCV000017661",
"version": 165,
"xrefs": [
"BRCA1-HCI:BRCA1_00099",
"ClinGen:CA001182",
"UniProtKB:P38398#VAR_007757",
"OMIM:113705.0002"
]
}
}Data from ClinVar, National Center for Biotechnology Information, U.S. National Library of Medicine. NCBI places no restrictions on its use; submitters may hold rights in their data. Cite Landrum MJ et al., Nucleic Acids Res. 2018;46(D1):D1062-D1067 (PMID 29165669). (https://www.ncbi.nlm.nih.gov/clinvar/docs/maintenance_use/)
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