A tool by Firecrawl · uses 6 tools · Healthcare

Adverse event signal triage for a marketed drug

Use when a pharmacovigilance scientist, medical affairs lead or hospital pharmacist sees a possible new safety signal for a marketed drug. Counts FAERS reports for the drug and reaction, checks whether the label already lists it, looks for published case reports and dedicated safety trials, and checks the EU regulatory picture, then rates the signal.

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Tools it calls

Each tool's price and track record across every agent today. Empty means the call worked and found nothing.

ToolPriceMedianSuccessEmpty

FDADrug eventsPrice5 creditsMedian–Success–Empty–
FDADrug labelsPrice5 creditsMedian–Success–Empty–
PubMed and PMCSearchPrice5 creditsMedian558 msSuccess99.2%Empty28.2%
PubMed and PMCArticlePrice5 creditsMedian291 msSuccess98.8%Empty0%
ClinicalTrials.govSearchPrice5 creditsMedian88 msSuccess100%Empty30.3%
European Medicines AgencyMedicinesPrice5 creditsMedian–Success–Empty–

Instructions

What your agent follows when it runs this tool. Paste them into any assistant connected to Firecrawl.

# Adverse event signal triage for a marketed drug

For one drug and one suspected reaction. The first question is whether the signal is new: already labelled, already studied, or genuinely unexplained.

## 1. Count the reports

1. Search @[FDA · Drug events](alexandria:fda-gov/records/drug_events) with an openFDA query on patient.drug.medicinalproduct and patient.reaction.reactionmeddrapt. Note **total_matching**, then sample records for seriousness, whether the drug was the suspect (drugcharacterization 1), reporter type and receive dates.
2. Run the same reaction against one or two drugs in the same class as a rough comparator.

## 2. Check the label

3. Search @[FDA · Drug labels](alexandria:fda-gov/records/drug_labels) for the brand. Read warnings, adverse reactions and post-marketing sections for the reaction or its synonyms.

## 3. Check the literature and trials

4. Search @[PubMed · PubMed search](alexandria:pubmed-ncbi-nlm-nih-gov/publications/search) for the drug plus reaction, including case reports. Read the top hits with @[PubMed · Article](alexandria:pubmed-ncbi-nlm-nih-gov/publications/article) for dechallenge and rechallenge detail.
5. Search @[ClinicalTrials.gov · Trial search](alexandria:clinicaltrials-gov/clinical-trials/search) for safety or post-marketing studies of the drug that measure this outcome.

## 4. Check Europe

6. Search @[EMA · Medicines](alexandria:ema-europa-eu/records/medicines) for the same active substance: authorisation status and any safety-related changes.

## Write the triage

- **Counts:** reports for the reaction, serious share, suspect share, trend by year, class comparator.
- **Label status:** listed, listed differently, or absent.
- **Evidence:** case reports with causality detail, relevant trials.
- **Rating:** known and labelled, plausible new signal, or noise, with the reasoning.
- **Caveats:** FAERS counts are not incidence and carry duplicates and reporting bias.
- **Sources:** cite safetyreportids, label ids, PMIDs and NCT ids. Say what could not be found.

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