Antibiotic pipeline health check

Tools it calls

Each tool's price and track record across every agent today. Empty means the call worked and found nothing.

# Antibiotic pipeline health check

For one pathogen or resistance pattern (for example carbapenem-resistant Enterobacterales). NCT numbers found in step 1 drive every later step.

## 1. What is in the clinic

1. List interventional trials with @[ClinicalTrials.gov · Trial search](alexandria:clinicaltrials-gov/clinical-trials/search) (condition the pathogen or infection, agg_filters phase 2 and 3). Keep NCT number, sponsor, intervention and status.
2. For every phase 3 or late phase 2 trial, read @[ClinicalTrials.gov · Study dates](alexandria:clinicaltrials-gov/clinical-trials/study_dates): are start and primary completion actual or estimated, and has the completion date moved? A slipped estimate is the cheapest early warning of trouble.
3. Open the two most advanced with @[ClinicalTrials.gov · Study record](alexandria:clinicaltrials-gov/clinical-trials/study) for comparator, enrolment target and primary endpoint.

## 2. What has already reached patients

4. Search @[FDA · Drug applications](alexandria:fda-gov/records/drug_applications) for each intervention name to see whether an application exists and its submission status.

## 3. What is funded upstream

5. Count early-stage work with @[NIH RePORTER · Search projects](alexandria:reporter-nih-gov/research-grants/search_projects) (text the pathogen with `antibacterial OR antimicrobial`, last two fiscal years).
6. Search @[PubMed · PubMed search](alexandria:pubmed-ncbi-nlm-nih-gov/publications/search) for recent reviews of the pathogen's treatment options to see which candidates experts already discount.

## Write the pipeline map

- **Pipeline table:** candidate, sponsor, phase, status, completion date (actual or estimated) and any slip.
- **Arrival windows:** earliest plausible approval per candidate, stated as a range with the reason.
- **Funding depth:** NIH project count behind the late-stage list.
- **Gaps:** mechanisms with nothing beyond phase 1.
- **Sources:** cite every figure to the capability and record it came from. Say what could not be found rather than guessing.

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